Fluid delivery device

ABSTRACT

Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

REFERENCE TO COPENDING APPLICATIONS

The entire subject matter, including materials submitted at filing, ofeach of:

-   -   U.S. Non-Provisional application Ser. No. 15/361,654, filed Nov.        28, 2016 entitled DRUG DELIVERY DEVICE;    -   U.S. Provisional application Ser. No. 62/434,760, filed Dec. 15,        2016 entitled DRUG DELIVERY DEVICE;    -   U.S. Provisional application Ser. No. 62/462,497, filed Feb. 23,        2017 entitled DRUG DELIVERY DEVICE;    -   U.S. Non-Provisional application Ser. No. 16/227,225, filed Dec.        20, 2018 entitled DRUG DELIVERY DEVICE; and    -   PCT application PCT/CA2017/051298 filed Nov. 1, 2017 entitled        FLUID DELIVERY DEVICE (and published as INTRADERMAL DRUG        DELIVERY DEVICE HAVING A LOCKED POST-DISPENSING CONFIGURATION)        is fully incorporated herein by reference.

FIELD

The present disclosure relates to fluid delivery devices and methods,for example intradermal drug delivery devices and methods.

BACKGROUND

There is a well-established need to improve drug delivery techniques, toreduce discomfort, while improving ease of handling and safety formedical professionals. The above mentioned application Ser. No.14/562,974, published as US 2014-0207078-A1 discloses a number ofapproaches to address this need.

The present disclosure aims to provide further novel approaches toovercome at least some drawbacks of known techniques, or at least thatprovides one or more useful alternatives.

SUMMARY

The following presents a simplified summary of the general inventiveconcept herein to provide a basic understanding of some aspects of theinvention. This summary is not an extensive overview of the invention.It is not intended to restrict key or critical elements of the inventionor to delineate the scope of the invention. Furthermore, any oneelement, feature, structure, function, of any aspect and/or exemplaryembodiment described in the present disclosure including the figures,clauses and/or claims herein, may be combined with any one or moreelements, features, structures, functions, and/or steps from the same orany other aspects and/or exemplary embodiments described in the presentdisclosure including the figures, clauses and/and claims herein.

In an aspect, there is provided a fluid dispenser comprising a barreldefining a longitudinal axis terminating at a first fluid delivery endregion; a dispenser body movable along the barrel relative to the firstfluid delivery end region in a first phase between a pre-dispensingconfiguration and a dispensed configuration, and in a second phasebetween the dispensed configuration and a locked post-dispensingconfiguration, wherein the dispenser body is configured to rotate aboutthe longitudinal axis during the first phase for aligned orientationwith at least one locking structure configured to lock the dispenserbody in the locked post-dispensing configuration during travel in thesecond phase.

In another aspect, there is provided a fluid dispenser comprising:

-   -   a. a barrel defining a longitudinal axis terminating at a first        fluid delivery end region;    -   b. a body movable along the barrel relative to the first fluid        dispensing end region, the body including:        -   i. a needle carrier aligned with the longitudinal axis and            terminating at a second fluid delivery end region, at which            is located a needle having a downstream end configured to            project through the first fluid delivery end region in a            first dispensing position;        -   ii. a plunger structure aligned with the longitudinal axis            and movable axially relative to the needle carrier; and        -   iii. a fluid capsule carrier which is configured to receive            a fluid capsule, the fluid capsule carrier being aligned            with the longitudinal axis and movable axially relative to            the needle carrier and the plunger structure;        -   iv. a latch interface operable under the action of a            compressive force between the barrel and the body, to            release the plunger structure to travel relative to the            needle carrier; and        -   v. the fluid capsule carrier configured, in a dispensing            mode, to travel toward piercing contact of the needle with            the fluid capsule.

In another aspect, there is provided a fluid dispenser comprising abarrel defining a longitudinal axis and terminating at a first fluiddelivery end region; a body movable along the barrel relative to thefirst fluid delivery end region, the body including a needle carrier, aplunger and a fluid capsule carrier therebetween, a latch interfacebetween the body and the barrel and responsive to a release forcetherebetween caused by compressive engagement of the barrel at a fluiddelivery site, to enable travel of the plunger and the fluid capsulecarrier toward the needle carrier, to a dispensing configuration inwhich an upstream end of a needle on the needle carrier extends into acapsule carrying region of the fluid capsule carrier and a downstreamend of the needle projects extends through the first fluid delivery endregion for delivery of a fluid thereto.

In another aspect, there is provided a fluid dispenser comprising abarrel defining a longitudinal axis terminating at a dispensing end; adispenser body movable along the barrel relative to the dispensing end,the dispenser body including a needle carrier, a plunger and a fluidcapsule carrier moveable relative to the needle carrier and the plunger,and a latch interface configured to release the dispenser body fortravel in the barrel in response to a release force between the barreland the dispenser body.

In another aspect, there is provided a fluid dispenser comprising abarrel defining a longitudinal axis terminating at a dispensing end; adispenser body movable along the barrel relative to the dispensing end,the dispenser body including a needle carrier, a plunger and a fluidcapsule carrier moveable relative to the needle carrier and the plunger,and a latch interface configured to release the dispenser body fordispensing travel in the barrel in response to a compressive engagementof the dispensing end at a fluid delivery site.

In another aspect, there is provided a fluid dispenser, comprising afluid capsule receiver configured to form a fluid capsule pressuringzone in a first capsule pressurizing mode, a needle carrier supporting afluid delivery needle, the needle carrier and the fluid capsule receiverconfigured to cause the needle to extend into the fluid capsulepressurizing zone to pierce the pressurized fluid capsule in a secondfluid capsule piercing mode; and a body containing the fluid capsulereceiver and the needle carrier, the fluid capsule receiver and theneedle carrier configured to move along the body to expose a fluiddelivery end of the needle in a third fluid delivery mode.

In another aspect, there is provided a method of dispensing a fluid froma fluid capsule, comprising:

-   -   locating a fluid capsule on a fluid capsule support surface;    -   displacing a plunger along an axis to toward engagement with the        fluid capsule;    -   pressurizing the fluid capsule between the plunger and the fluid        capsule support surface, so that a membrane of the fluid capsule        against the fluid capsule support surface is in a tensioned        needle receiving configuration;    -   displacing the plunger and the fluid capsule support, with the        fluid capsule in the needle receiving configuration toward a        needle support to cause a capsule-piercing end of a fluid        delivery needle thereon, to extend through the fluid capsule        support surface to penetrate the membrane to initiate onset of        dispensing of fluid through the needle; and    -   advancing the plunger, the fluid capsule support and the needle        support toward a fluid delivery configuration with an opposite        fluid delivery end of the needle exposed to penetrate a delivery        location.

In another aspect, there is provided a method of securing a dispensingdevice following delivery of a fluid therefrom, comprising providing abarrel defining a longitudinal axis terminating at a first fluiddelivery end region and a dispenser body movable along the barrelrelative to the first fluid delivery end region, the dispenser bodymovable in a first phase between a pre-dispensing configuration and adispensed configuration, and in a second phase between the dispensedconfiguration and a locked post-dispensing configuration, wherein thedispenser body is configured to rotate about the longitudinal axis, atleast in part, during the first phase for aligned orientation with atleast one locking structure during travel in the second phase.

In another aspect, there is provided a method of securing a dispensingdevice following delivery of a fluid therefrom, comprising:

-   -   providing a barrel defining a longitudinal axis terminating at a        first fluid delivery end region and a dispenser body movable        along the barrel relative to the first fluid delivery end        region;    -   displacing the dispenser body in a first phase between a        pre-dispensing configuration and a dispensed configuration, and        in a second phase between the dispensed configuration and a        locked post-dispensing configuration, wherein the dispenser body        is rotated about the longitudinal axis, at least in part, during        the first phase and/or the second phase for aligned orientation        with at least one locking structure during travel in the second        phase.

In another aspect, there is provided a fluid dispenser comprising abarrel defining a longitudinal axis terminating at a first fluiddelivery end region; a dispenser body movable along the barrel relativeto the first fluid delivery end region in a first phase between apre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispenser body is configuredto rotate about the longitudinal axis during the first phase and/or thesecond phase for aligned orientation with at least one locking structureconfigured to lock the dispenser body in the locked post-dispensingconfiguration during travel in the second phase.

In another aspect, there is provided a fluid dispenser comprisinghousing means defining a longitudinal axis terminating at a first fluiddelivery end region; dispensing means movable along the housing meansrelative to the first fluid delivery end region in a first phase betweena pre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispensing means isconfigured to rotate about the longitudinal axis during the first phaseand/or the second phase for aligned orientation with at least onelocking means during travel in the second phase.

In another aspect, there is provided a fluid dispenser comprisinghousing means defining a longitudinal axis terminating at a first fluiddelivery end region; dispensing means movable along the housing meansrelative to the first fluid delivery end region in a first phase betweena pre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispensing means isconfigured to rotate about the longitudinal axis during the first phasefor aligned orientation with at least one locking means during travel inthe second phase.

BRIEF DESCRIPTION OF THE DRAWINGS

Several exemplary embodiments will be provided, by way of examples only,with reference to the appended drawings, wherein:

FIGS. 1, 2 and 3 to 4 are, respectively, side, sectional and assemblyviews of a dispenser;

FIGS. 5 to 10 are side or sectional views of the dispenser of FIG. 1 indifferent configurations;

FIGS. 11 to 13 are perspective or side assembly views of structures ofthe dispenser of FIG. 1;

FIG. 12a is a top plan view of a structure shown in FIG. 12;

FIGS. 14 to 16 are perspective or side views of structures of thedispenser of FIG. 1;

FIG. 15a is a top plan view of a structure shown in FIG. 15;

FIGS. 17 to 19 are perspective or side views of a structure of thedispenser of FIG. 1;

FIGS. 18a and 19a are top plan views of the structure shown in FIGS. 18and 19 respectively;

FIGS. 20 to 24 are perspective or side views of a structure of thedispenser of FIG. 1;

FIGS. 21a and 21b are top and bottom plan views, respectively, of thestructure shown in FIG. 21;

FIGS. 25 to 31 are perspective views of structures of the dispenser ofFIG. 1;

FIGS. 32 to 35 are sectional views showing additional features of thedispenser of FIG. 1; and

FIGS. 36 to 56 are views showing another dispenser and/or structuresthereof.

DESCRIPTION OF THE EXEMPLARY EMBODIMENTS

It should be understood that the invention is not limited in itsapplication to the details of construction and the arrangement ofcomponents set forth in the following description or illustrated in thedrawings. The invention is capable of other embodiments and of beingpracticed or of being carried out in various ways. Also, it is to beunderstood that the phraseology and terminology used herein is for thepurpose of description and should not be regarded as limiting. The useof “including,” “comprising,” or “having” and variations thereof hereinis meant to encompass the items listed thereafter and equivalentsthereof as well as additional items. Unless limited otherwise, the terms“connected,” “coupled,” and “mounted,” and variations thereof herein areused broadly and encompass direct and indirect connections, couplings,and mountings. In addition, the terms “connected” and “coupled” andvariations thereof are not restricted to physical or mechanicalconnections or couplings. Furthermore, and as described in subsequentparagraphs, the specific mechanical and/or other configurationsillustrated in the drawings are intended to exemplify embodiments of theinvention. However, other alternative mechanical and/or electrical orother configurations are possible which are considered to be within theteachings of the present disclosure.

Exemplary embodiments herein may be used to deliver a variety of activeagents. The term “drug” is used loosely herein to refer to prophylacticas well as therapeutic agents. For example, vaccines may be deliveredusing the device. In addition, the term refers broadly to active agents,such as nucleic acids, small molecules, therapeutic proteins, hormones,analgesics, etc. in additional to traditional pharmacologic agents.Typical drugs include peptides, proteins or hormones such as insulin,calcitonin, calcitonin gene regulating protein, atrial natriureticprotein, colony stimulating factor, betaseton, erythropoietin (EPO),interferons such as α, β, or γ interferon, somatropin, somatotropin,somatostatin, insulin-like growth factor (somatomedins), luteinizinghormone releasing hormone (LHRH), tissue plasminogen activator (TPA),growth hormone release hormone (GHRH), oxytocin, estradiol, growthhormones, leuprolide acetate, factor VIII, interleukins such asinterleukin-2, and analogues thereof; analgesics such as fentanyl,sufentanil, butorphanol, buprenorphine, levorphanol, morphine,hydromorphone, hydrocodone, oxymorephone, methadone, lidocaine,bupivacaine, diclofenac, naproxen, pavefin, and analogues thereof;anti-migraine agents such as sumatriptan, ergot alkaloids, and analoguesthereof, anti-coagulant agents such as hepafin, hirudin, and analoguesthereof; anti-emetic agents such as scopolamine, ondansetron,domperidone, metoclopramide, and analogues thereof; cardiovascularagents, anti-hypertensive agents and vasodilator such as diltiazem,clonidine, nifedipine, verapamil, isosorbide-5-mononitrate, organicnitrates, agents used in treatment of heart disorders, and analoguesthereof; sedatives such as benzodiazepines, phenothiozines, andanalogues thereof; narcotic antagonists such as naltrexone, naloxone,and analogues thereof; chelating agents such as deferoxamine, andanalogues thereof; anti-diuretic agents such as desmopressin,vasopressin, and analogues thereof; antineoplastics such as5-fluorouracil, bleomycin, and analogues thereof; prostaglandins andanalogues thereof; and chemotherapy agents such as vincristine, andanalogues thereof. Stabilized preparations of drugs that can be storedat room temperature are particularly preferred for use in the device andmethod.

The term “fluid” refers to any fluid containing, or not containing, adrug, an active agent or communication of drugs or agents, that can passthrough the cannula of the microneedle. This includes a liquid, asolution, a gel, a dispersion or a fine suspension.

Referring to FIGS. 1 to 4, there is provided an exemplary embodiment ofa dispenser 10 for dispensing a fluid such as one containing a drug.While the dispenser 10 may be deployed for non-drug-containing fluids,the following discussion is provided with respect to drug containingfluids.

The dispenser 10 comprises a barrel (or housing) 12, defining alongitudinal axis A terminating at a first fluid delivery end region 14.A body, generally shown at 20, is movable along the barrel 12 relativeto the first fluid delivery end region 14. The body 20 includes a needlecarrier 22 aligned with the longitudinal axis A and terminating at asecond fluid delivery end region 24, at which is located a needle 26.The needle 26 has an upstream end 26 a which is exposed inwardly topierce a membrane 30 a on a fluid capsule 30, and a downstream end 26 b(as shown in dashed lines in FIG. 10) configured to project through thefirst fluid delivery end region 14 to deliver the fluid in a firstdispensing position.

A plunger structure 34 is aligned with the longitudinal axis A andmovable axially relative to the needle carrier 22, while a fluid capsulecarrier 40 is aligned with the longitudinal axis A and movable axiallyrelative to the needle carrier 22 and the plunger structure 34. As willbe described, a latch interface (a portion of which is generally shownat 46 in FIG. 4) is operable under the action of a compressive force C(FIG. 1) acting against the barrel 12 and the body 20, to release theplunger structure 34, so that it can travel relative to the needlecarrier 22.

The fluid capsule carrier 40 is configured, in a first phase (ordispensing mode) to travel toward piercing contact by the upstream end26 a of needle 26 with the membrane 30 a. In some cases, the fluidcapsule carrier 40 is configured to travel with the plunger structure34, for at least part of the first phase.

In some exemplary embodiments, for at least part of the dispensing mode,the fluid capsule carrier 40 is further configured to rotate axiallybetween a lock-unaligned angular position (as generally shown in FIGS.26 and 27) and a lock-aligned angular position (as generally shown inFIGS. 28 and 29). This may be provided, with reference to FIGS. 5 to 10,by at least one rotation interface, as will be described, which isprovided across a pair of first cooperating elements respectively on thefluid capsule carrier 40 and at least one of the plunger structure 34and the needle carrier 22. In the example shown in FIG. 5, the at leastone rotation interface includes a first rotation interface 50 providedbetween the fluid capsule carrier 40 and the plunger structure 34, eachincluding one of a corresponding first set of first cooperatingelements, including at least one first guide path 54 and at least onefirst follower 56 to travel along the guide path 54. As can be seen inFIG. 5, the first guide path 54 is ramped, but may be otherconfigurations such as stepped, or shaped in various ways, such as theangular shape shown, or alternatively shaped as a parabola or the like.Thus, in some exemplary embodiments, the complementary guide formationsbetween the fluid capsule carrier 40 and the plunger 36 enable them torotate together while the needle carrier 22 and the plunger supporttravel along the barrel toward the first dispensing position as shown inFIG. 28.

The first follower 56 in the first set of first cooperating elements isprovided, in this example, as a follower flange 56 which extendslaterally outwardly from a plunger support 38, forming an end region 56a. Thus, as the end region 56 a travels along the first guide path 54 asshown by path B1, the plunger structure 34 rotates in a spiral aboutlongitudinal axis A in a downward direction as viewed in FIG. 5.

Continuing with reference to FIG. 5, the fluid capsule carrier 40includes a generally cylindrical capsule carrier body 40 a with an openend region 40 b, which is opposite the second fluid delivery end region24 and receives the plunger structure 34 therethrough. A pair ofsymmetrically oriented projections 42 are positioned adjacent the openend region 40 b with at least one, in this case two, first guide paths54 formed on outward edge regions thereon. Thus, the first guide paths54 are operatively oriented near the open end region to engage thecorresponding pair of symmetrically disposed first followers 56 on theplunger structure 34.

Referring to FIGS. 2, 5, and 17 to 19 a, in some exemplary embodiments,the at least one rotation interface includes a second rotation interface60 provided between the fluid capsule carrier 40 and the needle carrier22. Each includes one of a corresponding second set of secondcooperating elements. In the case of the fluid capsule carrier 40, apair of symmetrically oriented second guide paths 62 is located relativeto the second fluid delivery end 24, and are formed by openings 62 a inthe cylindrical carrier body 40 a. The second guide paths 62 areoperatively oriented near the second fluid delivery end region 24 toalign with, and engage, at least one second follower 61 on the needlecarrier 22 (FIG. 17) which, in this case, is provided by way of a pairof second followers 64 as edge surfaces on an inner face 22 b on theneedle carrier 22. Thus, the capsule carrier body 40 a provides a pairof first guide paths 54 and a pair of second guide paths 62, each pairbeing symmetrically arranged relative to the longitudinal axis A andinterfacing with corresponding first followers 56 (on the plungerstructure 34) and second followers 64 (on the needle carrier 22).

It will be understood that “guide path” and “follower” are relativeterms to identify two components of an interface. Such terms are notintended to restrict the components to a particular function unique to aguide and a follower respectively, since they are both respondingrelative to one another to forces exerted externally. Thus, it may beconsidered that the guide paths are, in some examples, following the netforces exerted on the fluid capsule carrier 40 as forces between theplunger structure 34 and the needle carrier 22, or the barrel 12.

Thus, in some embodiments, each of the first and second rotationinterfaces 50, 60 may provide two pairs of cooperating elements to guiderotation of the fluid capsule carrier 40 relative to the plungerstructure and/or the needle carrier, in order to transfer the fluidcapsule carrier to the lock-aligned angular position. As will bedescribed, however, this relative rotation may also controllably enablethe plunger to be released to pressurize the fluid capsule. Movementprovided by both rotational interfaces may be controlled by a latchinterface so that both actions occur in a designated manner.

Referring to FIGS. 2 to 4, the fluid capsule carrier 40 includes a fluidcapsule receiving surface 44, which in this exemplary embodiment isgenerally transverse relative to the longitudinal axis A, and a needlepassage 44 a extending therethrough to receive the upstream end 26 a ofthe needle 26 in the first dispensing position. Referring further toFIGS. 11 to 13, the plunger structure 34 includes a plunger end region34 a to travel during the dispensing mode toward a second dispensedposition adjacent the capsule receiving surface 44 and to cooperatetherewith to pressurize the fluid capsule 30, thereby to express thefluid through the needle 26.

Referring to FIGS. 3, 4, and 11 to 14, the plunger structure 34 includesa plunger 36 and a plunger support 38. As will be described, the plunger36 is configured to swivel through at least a predetermined range aboutthe longitudinal axis A and relative to the plunger support 38 so as torotate together with the fluid capsule carrier 40. The plunger supportincludes a central circular passage 38 d (FIG. 12a ) which has an endregion with a pair of opposed guide windows 38 e. The plunger has anumber of stabilizers 36 b spaced therealong to engage the circularpassage 38 d, as well as a pair of opposed tabs 36 a, each of which isreceived in a corresponding guide window 38 e. Further, the fluidcapsule carrier 40 and plunger 36 are configured to fix an angularposition of the plunger 36 relative to the fluid capsule carrier 40 atleast during the dispensing mode.

Referring to FIGS. 11 and 14, the fluid capsule carrier 40 and plunger36 are provided with complementary guide formations, which includes atleast one laterally (in this case the two) outwardly extending tabs 36 aand a corresponding pair of longitudinal grooves 43 formed in an innersurface 40 c of the fluid capsule carrier 40. Thus, the engagement ofthe tabs 36 a with the grooves 43 configures the plunger support 38 tofollow fluid capsule carrier 40, in the dispensing mode. The guidewindows 38 e thus allow for rotation of the tabs 36 a within adesignated angular range according to the width of the guide windows 38e.

In some exemplary embodiments, and as shown in FIGS. 17 and 24, theneedle carrier 22 and barrel 12 may further include complementaryformations aligned with the longitudinal axis A to form a needle carriertravel path along the longitudinal axis A, while inhibiting relativerotation of the needle carrier 22 relative to the barrel 12. In thiscase, the needle carrier 22 includes a pair of spaced flanges 22 a whichare aligned with the longitudinal axis A to engage corresponding spacedflanges 15 (FIG. 24) extending inwardly along the inner surface 12 a ofthe barrel 12. In this case, the spacing between the flanges 22 a isrelatively larger than the spacing between the flanges 15, to receivethe flanges 15 between the flanges 22 a, though this configuration maybe reversed or configured in other ways to inhibit relative rotationbetween the needle carrier and barrel. That said, there may in otherexemplary embodiments in which relative rotation between the needlecarrier and barrel may be beneficial.

Referring to FIG. 18, the needle carrier 22 is further provided with twopairs of central body structures which extend in a manner to define alateral periphery and terminate at a corresponding pair of passages 25 awhich are each configured to receive one of a pair of locking tabs 72(FIG. 20) on the fluid capsule carrier 40 during assembly. The lowerboundary of the passage 25 a, as viewed in FIG. 18, is tapered in amanner to permit one way travel of the locking tab downwardly.Installing of the fluid capsule carrier 40 with the needle carrier 22thus involves passing the locking tabs 72 along each of the passages 25a and passed the tapered lower boundary, thus requiring a slight lateralflexing of the needle carrier according to arrows F to open the taperedlower boundary to allow the locking tabs therethrough.

Referring to FIGS. 2 to 4, 20 to 29, in some exemplary embodiments, thedispenser 10 may further comprise a lock interface 70 to fix thedispenser with needle carrier 22 in a retracted position at a lockinglocation, when the fluid capsule carrier 40 is in a lock-aligned angularposition. In this configuration, the downstream end 26 b is retractedwithin the barrel 12, i.e. so that it is not projecting beyond the firstfluid delivery end region 14. This may thus be achieved while the needlecarrier 22 is biased to travel from the dispensed position to thelocking location. In this case, the bias may be provided by at least onecompression spring, in this case a pair of compression springs 80,acting between the first and second delivery end regions 14 and 24, andlocated in seating recesses 80 a, 80 b on the inwardly facing wall ofthe barrel 12 (FIG. 21a ) and on the adjacent facing surface of theneedle carrier 22 (FIG. 19a ), respectively.

In some exemplary embodiments, both the latch and lock interfaces 46, 70may utilize at least one, in this case the pair of opposed locking tabs72 extending laterally outwardly from the fluid capsule carrier 40. Inthe case of the latch interface 46, the locking tabs 72 are each alignedwith one of a pair of opposed symmetrical axial latch formations 74, oneof which is shown in FIGS. 20 and 23, which extends along an innersurface 12 a of the barrel 12 and terminating at a transition region 76.Each locking tab 72 is configured to travel (as shown by path D1) alonga first adjacent region 74 a of the axial latch formation 74 (in alock-nonaligned angular position), during which time the axial latchformation 74 functions as a barrier to interrupt rotation of the fluidcapsule carrier 40 about axis A, which would otherwise require lateraltravel of the locking tabs 22 in the direction of their respective axiallatch formations 74. Meanwhile, the latch interface 46 enables the body20 to travel relative to the barrel 12 against the biasing action of thecompression springs 80 which in the example of dispenser 10 may beovercome by the user pressing on the plunger structure 34 with thebarrel 12 placed against the fluid delivery site. This travel is causedby compression force C acting between the plunger structure 34 and thebarrel 12, against the opposing biasing force of compression springs 80.

Each axial latch formation 74 is bevelled in the transition region 76,as can best be seen in FIGS. 23 and 24, in a manner which takes intoaccount (and in this example matches) the outer profile of the lockingtab 72 (as can be seen in FIG. 26), enabling the latter to pass over thetransition region 76, to a lock-aligned angular position (shown in FIG.28) during rotational movement of the fluid capsule carrier 40 relativeto the needle carrier 22. Thus, the latch interface 70 is released, oncethe locking tabs 72 pass through their respective transition regions 76,as occurs along path D2.

When in the lock-aligned angular position, the fluid capsule carrier 40is thus movable axially under the action of the plunger structure 34,against the biasing force of the compression springs 80, correspondingto the locking tabs 72 travelling along path D3. This position maycorrespond to, or be upstream of, the piercing of the membrane 30 a bythe upstream end 26 a of the needle 26. In either case, the fluidcapsule 30 may move axially in the direction of the needle 26 until theplunger end region 34 a engages the fluid capsule 30, therebycooperating with the transverse capsule receiving surface 44 topressurize the fluid capsule 30 and forcing fluid through the needle toexit from the downstream end 26 b. The plunger end region 34 a reaches adispensed position when it fully engages the transverse capsulereceiving surface 44, via a collapsed (and essentially empty or void)fluid capsule. Meanwhile, the locking tabs 72 are in their lock-alignedpositions, but not yet at their locking location.

In some exemplary embodiments, as can be seen in FIG. 23, the lockinterface may be provided between the locking tabs 72, when in theirlock-aligned angular positions, and a transverse locking flange 78extending transversely across the surface of the barrel 12 andpositioned at a location adjacent to the transition region 76, andcorresponding to a designated locking location, and which is located ona second region 74 b of the locking edge formation. The locking tabs 72may thus be configured, with release of the fluid capsule carrier 40 andunder the consequent bias of compression springs 80, to travel alongpath E toward and pass over the transverse locking flange 78, under theaction of their live hinge resiliency, to a locking location, as shownin FIG. 29. In this position, the locking tabs are behind and againsttheir respective locking flanges 78, thus prevented from travelling backtoward the first fluid delivery end region 14.

Thus, in some exemplary embodiments, the latch interface 46 and the lockinterface 70 may provide for both controlled dispensing of fluid and fora locking of the dispenser with the needle 26 in a retracted positionwithin the barrel 12 following dispensing.

Referring to FIGS. 4, 17 and 32 to 35, in some exemplary embodiments,the dispenser 10 may be provided with a lock interface 70 betweenlocking tabs 38 f on the plunger support 38 (as can be seen in FIG. 4)and aligned bosses 22 c on the needle support 22 (FIG. 17), to lock theplunger support 38 (and hence the plunger 36) and the needle support 22following fully dispensing of the contents of the fluid capsule 30.Interaction between the locking tabs 38 f and bosses 22 c may be seen insuccessive unlocked and locked positions shown by FIGS. 34 and 35.

In the fully dispensed position, as shown in FIG. 35, the upstream end26 a of the needle 26 is shown extending into the needle passage 44 a,and thus piercing both sides of the fluid capsule 30 at this stage. Thatsaid, the capsule, the needle and/or the needle passage 44 a may bemutually configured to allow the fluid capsule to gather into the needlepassage 44 a or otherwise not to be penetrated by the needle.

Thus, as the plunger support 38 approaches the fully dispensed position,the locking tabs 38 f flex over the corresponding locking formations, inthis exemplary embodiment in the form of bosses 22 c. Due to their livehinge resiliency, the locking tabs 38 f may be configured to audibly“click” into the locked position as shown in FIG. 35 when reaching thefully dispensed position. Thus, the lock interface 70 achieves, in thisinstance, two roles. Firstly, it secures the plunger support 38 (andthus the plunger 36) with the needle carrier 22 in a lockedconfiguration, so that further displacement to the locked position alongpath E, as shown in FIG. 23, may occur with the plunger support 38, theplunger 36 and the needle carrier 22 traveling in unison.

Secondly, the locking tabs 38 f are one example of a configuration toemit an audible sound or other signal indicative of the use of thedispenser 10 reaching the second dispensed position. That said, thedispenser 10 may be configured in other ways to emit a sound audible toa user of the dispenser 10 indicative of the plunger 36 reaching thesecond dispensed position, as may be provided by other noise emittingconfigurations including other mechanical configurations using one ormore biased noise emitting elements, either through the use of naturalmaterial resiliency, springs, magnetics or the like, or electronicallythrough a noise emitting position sensor or the like.

Referring to FIG. 25, the dispenser 10 further comprises at least one,and in this instance a pair of user gripping tabs 84 extending outwardlyfrom the needle carrier 22 for a user to engage with two fingers formanipulating the dispenser 10, through the dispensing mode.

Thus, in some exemplary embodiments, the actions of the dispenser 10 mayinvolve, in sequence, a release mode in which the dispenser 10transitions from a pre-dispensing locked configuration which enables thedispenser 10 to be manufactured, packaged and shipped to a dispensingsite with reduced risk of incidental release of the fluid contained influid capsule 30, that is by inhibiting conditions during shipping orpreparations that would deliver force C to the dispenser. The dispensingsite may be, for instance, at a remote location and staffed by volunteerusers who may not be practiced in the operation of a standard syringe.Further, the pre-dispensing locked configuration enables the dispenser10 to be unpackaged and prepared for dispensing, with reduced risk ofinadvertent contact with the needle, and with reduced risk ofinadvertent dispensing of the fluid. At this time the dispenser 10, andthe fluid delivery site on a patient, may be prepared.

To dispense the fluid, the user may grip the dispenser 10 by engagingthe user gripping tabs 84 with the index and middle fingers and an outerend region of the plunger structure 34 with the thumb. In thiscondition, the dispenser 10 is locked from dispensing as a result of theengaged latch interface 46, that is by the locking tabs 72 of thecorresponding axial latch formations 74 (FIG. 25), that is being locatedin the first adjacent region 74 a (as shown in FIG. 23), thus preventingrotation of the fluid capsule carrier 40 relative to the needle carrier22 and the plunger structure 34. Without that rotation, the plungerstructure 34 is unable to travel toward the fluid capsule carrier 40 topressurize the fluid capsule 30. However, in this configuration, theplunger structure 34 is moveable longitudinally relative to the barrel12 when compressive force C is exerted on the compression springs 80,which occurs when the dispenser 10 is placed on and pressed against thefluid delivery site on the patient.

Referring to FIGS. 23 and 25, under compressive force C, the dispenser10 moves toward the transition from the pre-dispensing locked mode(corresponding to path D1 of FIG. 23) to the dispensing mode, whichoccurs when the locking tabs 72 reach and traverse the bevelledtransition regions 76 on the axial latch formations 74 (FIG. 25), alongpath D2. Thus the dispensing mode involves a first rotation phase duringwhich the fluid capsule carrier 40 rotates relative to the needlecarrier 22, as seen by the movement of the tabs 72 to their positionshown in FIG. 28 (corresponding to path D2 of FIG. 23). The first andsecond followers 56 and 64 may then travel along the first and secondguide paths 54, 62 (corresponding to path D3 of FIG. 23), withcorresponding axial movement of the plunger end region 34 a towardengagement with the fluid capsule 30. Thus, FIGS. 27 and 28 show a firstrotation phase during which the fluid capsule carrier 40 rotatesrelative to the needle carrier 22 about the longitudinal axis A, whilethe plunger end region 34 a approaches the capsule receiving surface 44.This can be seen by the corresponding follower member travelling alongthe guide surface from a starting position, which will depend on therelative configurations of the guide surface and the follower member,though in the illustrated example is a central location the guidesurface.

Thus, (and referring to FIG. 5) during the first rotation phase, thefirst followers 56 travel along the first guide paths 54, in thedirection of path B1, occurring together with travel of the tabs 72along path D2. The first followers 56 then reach the onset of a seconddispensing phase as they pass beyond the first guide paths anddownwardly, as viewed in FIG. 2, in the direction of path B2, whichcorresponds to travel of the tabs 72 along path D3 (in FIG. 29) . Itwill be understood that the separate paths D2 and D3 are exemplary and,in some cases, may be axial and tangential components of a helical pathabout longitudinal axis A.

In some exemplary embodiments, in the second dispensing phase, the pointin travel of the first follower 56 at the transition point betweenarrows B1 and B2, may be configured to correspond generally to thebeginning of contact between the plunger end region 34 a and the capsule30, while the travel of the first follower 56 generally ends at, ornear, a limit surface 40 d at the open end region 40 b, as the plungerend region reaches engagement with the transverse capsule receivingsurface 44 and thus a substantial completion of the dispensing of fluidin the fluid capsule 30 between them. It thus follows that the travel ofthe first follower 56 from the transition point toward the limit surface40 d corresponds to the dispensing of the fluid. Thus, the dispensingmode includes a second dispensing phase during which the plunger endregion 34 a is movable axially relative to the capsule receiving surface44 toward the second dispensed position to pressurize the fluid capsule30 and dispense the fluid.

The locking mode then follows by the release of the plunger 36 and thegripping tabs 84, thus causing the compression springs 80 to bias thebody 20, and thus the locking tabs 72 towards their locked position withthe locking flange 78 as shown in FIG. 29.

Referring to FIGS. 3, 20, 23, 25 and 26, another lock interface is shownat 88 (FIG. 25) and is provided by a complementary formation, in theform of a boss 12 c in the side wall of the barrel 12, and locatedimmediately above a passage shown at 12 b. The boss 12 c is aligned witha tab 22 d (FIG. 26) outwardly extending from the needle carrier 22,which engages the boss 12 c when the needle carrier is assembled withthe barrel at the onset of the dispensing mode, as can be seen in FIG.25. The lock interface 88 in this case is provided to lock the needlecarrier 22 in position by engaging the tab 22 d with the boss 12 c. Thepassage 12 b is provided in this case to enable them to be disassembled.In a commercial setting, the passage 12 b may not be required and maythus be omitted, thus making the needle carrier effectively permanentlyinstalled in the barrel once the tab 22 d and boss 12 c are engaged.

Referring to FIGS. 3 to 10, looking more closely at the fluid capsule30, even though the membrane 30 a is shown to be relatively convex inFIGS. 3 and 4, which may occur in some cases when in a filled condition.On the other hand, the membrane 30 a may also maintain a planarconfiguration. In either case, the membrane is joined to a sphericalbody 30 b, by way of an ultrasonic weld seam or the like. The membrane30 a, by its flexible nature, will follow the shape of the transversecapsule receiving surface which is slightly concave to provide for afunctional seating of the outer surface of the membrane 30 a therein.When the fluid capsule 30 is in position on the fluid capsule carrier40, the spherical body 30 b is thus aligned with and engages the exposedsurface 34 b of the plunger end region 34 a. The generally convex shapeof the exposed surface 34 b of the plunger (that is exposed to the fluidcapsule 30) is complementary with the generally concave shape of thetransverse fluid capsule receiving surface so that, when pressedtogether, they may substantially completely evacuate the cavity whenreaching the dispensed position, as shown in FIG. 10. Thus, as thesurface 34 b approaches surface 44, internal pressure in the fluidcapsule 30 increases to result in lateral tension on the membrane 30 awhich tends to stretch the membrane, in other words in a manner thatwill tend to increase the surface area of the membrane 30 a. Thus, thetension in the membrane 30 a enhances the piercing thereof by theupstream end 26 a of the needle 26, to minimize a tendency that mayotherwise arise for the membrane material to gather around the needleand thus delaying the onset of needle penetration and dispensing.

The transition between the membrane 30 a and the spherical body 30 b maybe formed between a base layer and a cover layer, wherein the base layerhas a planar zone to define the membrane 30 a and a spherical region todefine the spherical body 30 b.

Referring to FIGS. 36 to 52, another fluid dispenser is shown at 92comprising a barrel 94 terminating at a first fluid delivery end region96 and a body 98. A cap 99 is provided to close a passage 96 a (FIG. 49)in the delivery end region 96. In this case, the barrel 94 includes apair of user gripping tabs 100 extending outwardly therefrom, enabling auser to establish a compressive force C between the barrel (via the usergripping tabs 100) and the body 98, without having to press the firstfluid delivery end region 96 against a dispensing site, for example on apatient. In other words, the compressive force C may be establishedbefore any contact is made between the first fluid delivery end region96 and the patient.

Referring to FIGS. 40 to 48, the body 98 includes a plunger support 102,plunger 103, and a needle carrier 104 (with passage 104 a to carry theneedle 105) which may be configured with formations, together with thebarrel 94, to form a guide interface 108 for minimizing rotationalmovement therebetween. In this example, the guide interface 108 includesat least one support passage (in this case a pair of support passages110) on the plunger support 102 which receive corresponding extendedsections 106 on the barrel 96. In this case, the pair of supportpassages 110 are provided by a pair of symmetrically opposedcircumferentially extended webs 114, each defining an outer periphery ofone of a corresponding pair of support passages. Further, the plungersupport 102 has a pair of ridged surface regions 118 between the webs114 and which engage a corresponding pair of grooved guide portions 112.

In use, the plunger support 102 thus moves relative to the needlecarrier 104 and the barrel 94, causing the guide portions 112 to travelalong the ridged surface regions 118, while the extended sections 106travel along the corresponding support passages 110, thus permittinglongitudinal travel along axis A, with relative rotational movement ofthe plunger support 102, the needle carrier 104 and the barrel 94blocked by the confining of the extended sections 106 to the boundariesof the support passages 110. Other configurations may be deployed tominimize rotational movement. Further, there may be some configurationsin which rotational movement between the plunger support 102 and theneedle carrier 104 may provide a useful functional purpose in somecases.

Referring to FIGS. 49 and 53 to 56, the cap 99 is provided with a bowtie shaped coupler 120 having an activating flange 122 to be held by theuser, which fits the similar bow tie shape of the passage 96 a, alongwith a base flange 124. Thus, installation of the cap 99 involvesaligning up the coupler 120 with the passage 96 a and extending thecoupler 120 into the passage 96 a until the base flange 124 engages theouter surface of the first fluid dispensing end 96. The cap 99 may thenbe rotated to bring the coupler 120 out of alignment with the passage,with the structure of the first fluid dispensing end 96 held between thecoupler 120 and the base flange 124, thus holding the cap 99 in place,until it is to be used. If desired, one or more further configurationsmay be provided to return the cap 99 in place, by providing additionalfrictional or latch configurations between the cap 99 and the structureof the first fluid dispensing end 96.

Thus, in some exemplary embodiments as the dispenser 92, the plunger 103and the fluid capsule carrier 128 provide a capsule receiver, which isconfigured to form a fluid capsule pressuring zone 126 in a firstcapsule pressurizing mode. The needle carrier 104 supports a fluiddelivery needle, and wherein the needle carrier and the fluid capsulereceiver are configured to cause the needle to extend into the capsulepressurizing zone to pierce the pressurized fluid capsule in a secondfluid capsule piercing mode. The fluid capsule carrier 128 and theneedle carrier 104 are configured to move along the body 98 to expose afluid delivery end of the needle 105 for a third fluid delivery mode.

In this case, the plunger 103 and fluid capsule carrier 128 havecomplementary surfaces to locate the fluid capsule therebetween. Atleast one interface is thus operable between the plunger support 102,the fluid capsule carrier 128, the needle carrier 104 and/or the body 98to enable displacement of the plunger relative to the fluid capsulecarrier in the first, second and third modes while exerting acompressive force at substantially consistent magnitude between theplunger support and the body

Thus, in some exemplary embodiments, the dispenser may configured toprovide a method or approach to secure the dispensing device followingdelivery of a fluid therefrom, by providing a barrel defining alongitudinal axis terminating at a first fluid delivery end region and adispenser body movable along the barrel relative to the first fluiddelivery end region. The dispenser body may then be displaced in a firstphase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispenser bodymay be rotated about the longitudinal axis, at least in part, during thefirst phase and/or the second phase for aligned orientation with atleast one locking structure so that the dispenser may be locked duringtravel in the second phase. Thus, structure features of exemplaryembodiments herein may be utilized without necessarily requiring theaction to align the dispenser body with the at least one lockingstructure to occur in the first phase. Rather, the second phase may beconfigured in some cases to provide the alignment, or a combination ofthe first and second phases.

Thus, some exemplary embodiments, for example the dispenser 92, enable amethod of dispensing a fluid from a fluid capsule, comprising:

a. locating a fluid capsule on a fluid capsule support surface definedin a fluid capsule;b. displacing a plunger along an axis to toward engagement with thefluid capsule;c. pressurizing the fluid capsule between the plunger and the fluidcapsule support so that a membrane of the fluid capsule against thefluid capsule support surface is in a tensioned needle receivingconfiguration;d. displacing the plunger and the fluid capsule support, with the fluidcapsule in the needle receiving configuration toward a needle support tocause a fluid capsule-piercing end of a fluid delivery needle to extendthrough the fluid capsule support surface to penetrate the membrane toinitiate onset of dispensing of fluid through the needle; ande. advancing the plunger, the fluid capsule support and the needlesupport toward a fluid delivery configuration with an opposite fluiddelivery end of the needle exposed to penetrate a user's skin.

CLAUSES

Exemplary embodiments as described herein, including dispensers andmethods, are described in the following clauses:

1. A fluid dispenser comprising a barrel defining a longitudinal axisterminating at a first fluid delivery end region; a dispenser bodymovable along the barrel relative to the first fluid delivery end regionin a first phase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispenser bodyis configured to rotate about the longitudinal axis during the firstphase for aligned orientation with at least one locking structureconfigured to lock the dispenser body in the locked post-dispensingconfiguration during travel in the second phase.2. A dispenser as defined in any of the preceding or following clauses,wherein the dispenser body includes a needle carrier with a second fluiddelivery end region defined thereon.3. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier is configured to be in a retracted positionwithin the barrel in the locked post-dispensing configuration.4. A dispenser as defined in any of the preceding or following clauses,wherein the dispenser body includes a fluid capsule carrier moveablerelative to the needle carrier in the first phase to dispense fluid froma carried capsule.5. A dispenser as defined in any of the preceding or following clauses,wherein the dispenser body includes a plunger structure movable relativeto the fluid capsule carrier in at least part of the first phase topressurize a carried capsule.6. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule carrier is configured, during at least part ofthe first phase, to travel with the plunger structure.7. A dispenser as defined in any of the preceding or following clauseswherein, during at least part of the first phase, the fluid capsulecarrier is configured to rotate axially between lock-unaligned andlock-aligned angular positions.8. A dispenser as defined in any of the preceding or following clauses,further comprising at least one rotation interface defined across aplurality of cooperating elements respectively on the fluid capsulecarrier and at least one of the plunger structure and the needlecarrier, to enable axial rotation of the fluid capsule carrier relativeto the barrel.9. A dispenser as defined in any of the preceding or following clauses,wherein the at least one rotation interface includes a first rotationinterface provided between the fluid capsule carrier and the plungerstructure, each including one of a corresponding first set of firstcooperating elements.10. A dispenser as defined in any of the preceding or following clauses,wherein the at least one rotation interface includes a second rotationinterface provided between the fluid capsule carrier and the needlecarrier, each including one of a corresponding second set of secondcooperating elements.11. A dispenser as defined in any of the preceding or following clauses,wherein the first and/or second cooperating elements include at leastone guide path and at least one follower to travel along the guide path.12. A dispenser as defined in any of the preceding or following clauses,wherein the guide path is ramped.13. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule carrier includes a capsule carrier bodycomprising an open end region opposite the second fluid delivery endregion to receive the plunger structure therethrough.14. A dispenser as defined in any of the preceding or following clauses,wherein the at least one first guide path is operatively oriented nearthe open end region to engage the first follower on the plungerstructure.15. A dispenser as defined in any of the preceding or following clauses,wherein the second guide path is operatively oriented near the secondfluid delivery end region to engage the second follower on the needlecarrier.16. A dispenser as defined in any of the preceding or following clauses,wherein the capsule carrier body is cylindrical and includes a pair offirst guide paths and a pair of second guide paths, each pair beingsymmetrically arranged relative to the longitudinal axis.17. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule carrier includes a transverse fluid capsulereceiving surface, and a needle passage extending therethrough toreceive an upstream end of a needle.18. A dispenser as defined in any of the preceding or following clauses,wherein the plunger structure includes a plunger end region to travelduring at least part of the first phase toward the fluid capsulereceiving surface to pressurize the fluid capsule, thereby to expressthe fluid through the needle.19. A dispenser as defined in any of the preceding or following clauses,wherein the first phase includes at least in part:

a. a first rotation phase during which the fluid capsule carrier isrotatable relative to the needle carrier about the longitudinal axis, asthe plunger end region approaches the fluid capsule receiving surface;and

b. a second dispensing phase during which the plunger end region ismovable axially relative to the fluid capsule receiving surface, atleast in part, to pressurize the fluid capsule.

20. A dispenser as defined in any of the preceding or following clauses,wherein during the second dispensing phase, at least in part, theplunger end region is movable axially with the fluid capsule receivingsurface, toward piercing contact with a needle on the needle carrier, todispense the fluid.21. A dispenser as defined in any of the preceding or following clauses,wherein the at least one locking structure includes a lock interface tofix the dispenser body at a locking location when the dispenser body isin the lock-aligned angular position.22. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier is biased to travel from the second dispensedposition to the locking location.23. A dispenser as defined in any of the preceding or following clauses,wherein the lock interface is configured between the fluid capsulecarrier and the barrel to engage when the dispenser is in thelock-aligned angular position.24. A dispenser as defined in any of the preceding or following clauses,further comprising at least one latch structure extending laterallyoutwardly from the fluid capsule carrier and at least one axial latchedge formation extending along an inner surface of the barrel andterminating at a transition region, wherein the latch structure isconfigured to travel along the axial latch edge formation toward andbeyond the transition, thereby to release the plunger structure.25. A dispenser as defined in any of the preceding or following clauses,wherein the at least one locking structure and the at least one latchstructure are each defined in common by a pair of locking tabs extendingoutwardly from the fluid capsule carrier.26. A dispenser as defined in any of the preceding or following clauses,wherein the bias is provided by at least one spring acting between thefirst and second fluid delivery end regions.27. A dispenser as defined in any of the preceding or following clauses,wherein the lock interface is configured between the at least onelocking structure extending laterally outwardly from the needle carrierand at least one transverse locking edge formation extendingtransversely across a surface of the barrel at the locking location,wherein the locking structure is configured to travel toward and engagethe transverse locking edge formation at the locking location when inthe lock-aligned angular position.28. A dispenser as defined in any of the preceding or following clauses,wherein the at least one locking structure includes at least one lockingtab extending laterally outwardly from the fluid capsule carrier toengage a corresponding locking edge formation on the barrel.29. A dispenser as defined in any of the preceding or following clauses,wherein the plunger structure includes a plunger and a plunger support,the plunger configured to swivel through at least a predetermined rangerelative to the plunger support to rotate with the fluid capsulecarrier.30. A dispenser as defined in any of the preceding or following clauses,the fluid capsule carrier and the plunger being configured to fix anangular position of the plunger relative to the fluid capsule carrier atleast during the first phase.31. A dispenser as defined in any of the preceding or following clauses,the fluid capsule carrier and the plunger further comprisingcomplementary guide formations to align the plunger with the fluidcapsule carrier.32. A dispenser as defined in any of the preceding or following clauses,wherein the guide formations include at least one laterally outwardlyextending tab on the plunger and at least one longitudinal groove formedin an inner surface of the fluid capsule carrier.33. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support and the needle carrier are configured to fixan angular position of the plunger support relative to the needlecarrier.34. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier and the plunger support include complementaryformations aligned with the longitudinal axis to form a plunger supporttravel path along the longitudinal axis.35. A dispenser as defined in any of the preceding or following clauses,wherein the complementary formations include a pair of flanges extendingfrom one of the needle carrier and the plunger support, to be receivedin complementary groove formations on the other of the needle carrierand the plunger support.36. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support includes a cover flange laterally outwardlyspaced to form an annular passage to receive an adjacent end region onthe barrel.37. A dispenser as defined in any of the preceding or following clauses,further comprising at least one user gripping tab extending outwardlyfrom the needle carrier or the barrel for a user to engage formanipulating the dispenser through at least part of the first phase.38. A dispenser as defined in any of the preceding or following clauses,further comprising a signal emitter to emit a signal indicating that theplunger structure has reached a dispensed position.39. A dispenser as defined in any of the preceding or following clauses,wherein the signal emitter includes a signal emitting interface betweenthe barrel and the dispenser body.40. A dispenser as defined in any of the preceding or following clauses,wherein the signal emitting interface includes at least one resilienttab and at least one locking formation aligned therewith, each of whichis located on one a respective one of the barrel and the dispenser body.41. A dispenser as defined in any of the preceding or following clauses,wherein the at least resilient tab extends from the plunger support andthe at least one locking formation is positioned on an inner surface ofthe barrel.42. A dispenser as defined in any of the preceding or following clauses,wherein the at least one resilient tab is locked in position with atleast one locking formation in the dispensed position.43. A dispenser as defined in any of the preceding or following clauses,further comprising a lock interface to lock the dispenser body relativeto the barrel in the dispensed position.44. A dispenser as defined in any of the preceding or following clauses,wherein the lock interface includes at least one resilient tab and aboss aligned therewith, each of which is located on one a respective oneof the barrel and the body.45. A dispenser as defined in any of the preceding or following clauses,wherein the resilient tab extends from the plunger support and the bossis positioned on an inner surface of the barrel.46. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support, the needle carrier and/or the barrelinclude formations to form a guide interface for inhibiting rotationalmovement therebetween.47. A dispenser as defined in any of the preceding or following clauses,wherein the guide interface includes at least one support passage toreceive an extended section on the barrel.48. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support includes a pair of symmetrically opposedcircumferentially extended webs, each defining an outer periphery of oneof a corresponding pair of support passages.49. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier includes a pair of opposed andcircumferentially cross sectioned guide sections to engage correspondingsurfaces on the plunger support.50. A fluid dispenser comprising:

a. a barrel defining a longitudinal axis terminating at a first fluiddelivery end region;

b. a body movable along the barrel relative to the first fluiddispensing end region, the body including:

i. a needle carrier aligned with the longitudinal axis and terminatingat a second fluid delivery end region, at which is located a needlehaving a downstream end configured to project through the first fluiddelivery end region in a first dispensing position;

ii. a plunger structure aligned with the longitudinal axis and movableaxially relative to the needle carrier; and

iii. a fluid capsule carrier which is configured to receive a fluidcapsule, the fluid capsule carrier being aligned with the longitudinalaxis and movable axially relative to the needle carrier and the plungerstructure;

iv. a latch interface operable under the action of a compressive forcebetween the barrel and the body, to release the plunger structure totravel relative to the needle carrier; and

v. the fluid capsule carrier configured, in a dispensing mode, to traveltoward piercing contact of the needle with the fluid capsule.

51. A dispenser as defined in clause any of the preceding or followingclauses, wherein the fluid capsule carrier is configured, in at leastpart of the dispensing mode, to travel with the plunger structure.52. A dispenser as defined in any of the preceding or following clauses,wherein, in at least part of the dispensing mode, the fluid capsulecarrier is configured to rotate axially between lock-unaligned andlock-aligned angular positions.53. A dispenser as defined in any of the preceding or following clauses,further comprising at least one rotation interface including a pluralityof cooperating elements respectively on the fluid capsule carrier and atleast one of the plunger structure and the needle carrier.54. A dispenser as defined in any of the preceding or following clauses,wherein the at least one rotation interface includes a first rotationinterface provided between the fluid capsule carrier and the plungerstructure , each including one of a corresponding first set of firstcooperating elements.55. A dispenser as defined in any of the preceding or following clauses,wherein the at least one rotation interface includes a second rotationinterface provided between the fluid capsule carrier and the needlecarrier, each including one of a corresponding second set of secondcooperating elements.56. A dispenser as defined any of the preceding or following clauses,wherein the first and/or second cooperating elements include at leastone guide path and at least one follower to travel along the guide path.57. A dispenser as defined in any of the preceding clauses, wherein theguide path is ramped.58. A dispenser as defined in any of the preceding or following clauses,wherein the follower in the first and/or second sets of cooperatingelements includes a follower guide path.59. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule carrier includes a capsule carrier bodycomprising an open end region opposite the second fluid delivery endregion to receive the plunger structure therethrough,60. A dispenser as defined in any of the preceding or following clauses,wherein at least one first guide path is operatively oriented near theopen end region to engage the first follower on the plunger structure,and at least one second guide path operatively oriented near the secondfluid delivery end region to engage the second follower on the needlecarrier.61. A dispenser as defined in any of the preceding or following clauses,wherein the capsule carrier body is cylindrical and includes a pair offirst guide paths and a pair of second guide paths, each pair beingsymmetrically arranged relative to the longitudinal axis.62. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule carrier includes a fluid capsule receivingsurface, and a needle passage extending therethrough to receive theupstream end of the needle in the first dispensing position, the plungerstructure including a plunger end region to travel during the dispensingmode toward a second dispensed position adjacent the fluid capsulereceiving surface and to cooperate therewith to pressurize the fluidcapsule, thereby to express the fluid through the needle.63. A dispenser as defined in any of the preceding or following clauses,wherein the dispensing mode includes at least in part:

a. a first rotation phase during which the fluid capsule carrier rotatesrelative to the needle carrier about the longitudinal axis, while theplunger end region approaches the fluid capsule receiving surface; and

b. a second dispensing phase during which the plunger end region ismovable axially relative to the fluid capsule receiving surface, atleast in part, to pressurize the fluid capsule and dispense the fluid.

64. A dispenser as defined in any of the preceding or following clauses,wherein during the second dispensing phase, at least in part, theplunger end region is movable axially with the fluid capsule receivingsurface, toward piercing contact with a needle on the needle carrier, todispense the fluid.65. A dispenser as defined in any of the preceding or following clauses,further comprising a lock interface to fix the body at a lockinglocation when the fluid capsule carrier is in the lock-aligned angularposition.66. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier is biased to travel from the second dispensedposition to the locking location.67. A dispenser as defined in any of the preceding or following clauses,wherein the bias is provided by at least one spring acting between thefirst and second fluid delivery end regions.68. A dispenser as defined in any of the preceding or following clauses,further comprising a latch interface configured between at least onelocking tab extending laterally outwardly from the fluid capsule carrierand at least one axial latch edge formation extending along an innersurface of the barrel and terminating at a transition region, whereinthe locking tab is configured to travel along the axial locking edgeformation under the action of the compressive force toward and beyondthe transition region, thereby to release the plunger structure fortravel relative to the fluid capsule carrier.69. A dispenser as defined in any of the preceding or following clauses,wherein the lock interface is configured between at least one lockingtab extending laterally outwardly from the fluid capsule carrier and atleast one transverse locking edge formation extending transverselyacross an inner surface of the barrel at the lock location, wherein thelocking tab is configured to travel toward and engage the transverselocking edge formation at the locking location when in the lock-alignedangular position.70. A dispenser as defined in any of the preceding or following clauses,wherein the at least one locking tab includes a pair of locking tabsextending laterally outwardly from the fluid capsule carrier.71. A dispenser as defined in any of the preceding or following clauses,wherein the plunger structure includes a plunger and a plunger support,the plunger configured to swivel through at least a predetermined rangerelative to the plunger support to rotate with the fluid capsulecarrier.72. A dispenser as defined in any of the preceding or following clauses,the fluid capsule carrier and the plunger being configured to fix anangular position of the plunger relative to the fluid capsule carrier atleast during the dispensing mode.73. A dispenser as defined any of the preceding or following clauses,the fluid capsule carrier and the plunger further comprisingcomplementary guide formations.74. A dispenser as defined in any of the preceding or following clauses,wherein the guide formations include at least one laterally outwardlyextending tab on the plunger and at least one longitudinal groove formedin an inner surface of the fluid capsule carrier.75. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support and the needle carrier are configured to fixan angular position of the plunger support relative to the needlecarrier in the dispensing mode.76. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier and the plunger support include complementaryformations aligned with the longitudinal axis to form a plunger supporttravel path along the longitudinal axis.77. A dispenser as defined in any of the preceding or following clauses,the complementary formations including a pair of flanges extending fromthe needle carrier toward the plunger support, to be received incomplementary groove formations on the plunger support.78. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support includes a cover flange laterally outwardlyspaced to form an annular passage to receive an adjacent end region onthe barrel.79. A dispenser as defined in any of the preceding or following clausesany, further comprising at least one user gripping tab extendingoutwardly from the needle carrier or the barrel for a user to engage formanipulating the dispenser through at least part of the dispensing mode.80. A dispenser as defined in any of the preceding or following clauses,further comprising a signal emitter to emit a signal indicating that theplunger structure has reached the second dispensed position.81. A dispenser as defined in any of the preceding or following clauses,wherein the signal emitter includes a signal emitting interface betweenthe barrel and the body.82. A dispenser as defined in any of the preceding or following clauses,wherein the signal emitting interface includes at least one resilienttab and at least one locking formation aligned therewith, each of whichis located on one a respective one of the barrel and the body.83. A dispenser as defined in any of the preceding or following clauses,wherein the resilient tab extends from the plunger support and at leastone locking formation is positioned on an inner surface of the barrel.84. A dispenser as defined any of the preceding or following clauses,wherein the resilient tab is locked in position with the at least onelocking formation in the second dispensed position.85. A dispenser as defined in any of the preceding or following clauses,further comprising a lock interface to lock the body relative to thebarrel in the second dispensed position.86. A dispenser as defined in any of the preceding or following clauses,wherein the lock interface includes at least one resilient tab and aboss aligned therewith, each of which is located on a respective one ofthe barrel and the body.87. A dispenser as defined in any of the preceding or following clauses,wherein the resilient tab extends from the plunger support and the bossis positioned on an inner surface of the barrel.88. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support, the needle carrier and/or the barrelinclude formations to form a guide interface for guiding movementtherebetween.89. A dispenser as defined in any of the preceding or following clauses,wherein the guide interface includes at least one support passage toreceive an extended section on the barrel.90. A dispenser as defined in any of the preceding or following clauses,wherein the plunger support includes a pair of symmetrically opposedcircumferentially extended webs, each defining an outer periphery of oneof a corresponding pair of support passages.91. A dispenser as defined in any of the preceding or following clauses,wherein the needle carrier includes a pair of opposed andcircumferentially cross sectioned guide sections to engage correspondingsurfaces on the plunger support.92. A fluid dispenser comprising a barrel defining a longitudinal axisand terminating at a first fluid delivery end region; a body movablealong the barrel relative to the first fluid delivery end region, thebody including a needle carrier, a plunger and a fluid capsule carriertherebetween, a latch interface between the body and the barrel andresponsive to a release force therebetween caused by compressiveengagement of the barrel at a fluid delivery site, to enable travel ofthe plunger and the fluid capsule carrier toward the needle carrier, toa dispensing configuration in which an upstream end of a needle on theneedle carrier extends into a capsule carrying region of the fluidcapsule carrier and a downstream end of the needle projects extendsthrough the first fluid delivery end region for delivery of a fluidthereto.93. A fluid dispenser comprising a barrel defining a longitudinal axisterminating at a dispensing end; a dispenser body movable along thebarrel relative to the dispensing end, the dispenser body including aneedle carrier, a plunger and a fluid capsule carrier moveable relativeto the needle carrier and the plunger, and a latch interface configuredto release the dispenser body for travel in the barrel in response to arelease force between the barrel and the dispenser body.94. A fluid dispenser comprising a barrel defining a longitudinal axisterminating at a dispensing end; a dispenser body movable along thebarrel relative to the dispensing end, the dispenser body including aneedle carrier, a plunger and a fluid capsule carrier moveable relativeto the needle carrier and the plunger, and a latch interface configuredto release the dispenser body for dispensing travel in the barrel inresponse to a compressive engagement of the dispensing end at a fluiddelivery site.95. A fluid dispenser, comprising a fluid capsule receiver configured toform a fluid capsule pressuring zone in a first capsule pressurizingmode, a needle carrier supporting a fluid delivery needle, the needlecarrier and the fluid capsule receiver configured to cause the needle toextend into the fluid capsule pressurizing zone to pierce thepressurized fluid capsule in a second fluid capsule piercing mode; and abody containing the fluid capsule receiver and the needle carrier, thefluid capsule receiver and the needle carrier configured to move alongthe body to expose a fluid delivery end of the needle in a third fluiddelivery mode.96. A dispenser as defined in any of the preceding or following clauses,wherein the fluid capsule receiver includes a plunger and a fluidcapsule carrier, the plunger and fluid capsule carrier havingcomplementary surfaces to locate the fluid capsule therebetween.97. A dispenser as defined in any of the preceding or following clauses,further comprising a plunger support to support the plunger, at leastone interface operable between the plunger support, the fluid capsulecarrier, the needle carrier and/or the body to enable displacement ofthe plunger relative to the fluid capsule carrier in the first, secondand/or third modes while exerting a compressive force at substantiallyconsistent magnitude between the plunger support and the body.98. A method of dispensing a fluid from a fluid capsule, comprising:

a. locating a fluid capsule on a fluid capsule support surface;

b. displacing a plunger along an axis to toward engagement with thefluid capsule;

c. pressurizing the fluid capsule between the plunger and the fluidcapsule support surface, so that a membrane of the fluid capsule againstthe fluid capsule support surface is in a tensioned needle receivingconfiguration;

d. displacing the plunger and the fluid capsule support, with the fluidcapsule in the needle receiving configuration toward a needle support tocause a capsule-piercing end of a fluid delivery needle thereon, toextend through the fluid capsule support surface to penetrate themembrane to initiate onset of dispensing of fluid through the needle;and

e. advancing the plunger, the fluid capsule support and the needlesupport toward a fluid delivery configuration with an opposite fluiddelivery end of the needle exposed to penetrate a delivery location.

99. A method of securing a dispensing device following delivery of afluid therefrom, comprising providing a barrel defining a longitudinalaxis terminating at a first fluid delivery end region and a dispenserbody movable along the barrel relative to the first fluid delivery endregion, the dispenser body movable in a first phase between apre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispenser body is configuredto rotate about the longitudinal axis, at least in part, during thefirst phase for aligned orientation with at least one locking structureduring travel in the second phase.100. A method of securing a dispensing device following delivery of afluid therefrom, comprising:

a. providing a barrel defining a longitudinal axis terminating at afirst fluid delivery end region and a dispenser body movable along thebarrel relative to the first fluid delivery end region;

b. displacing the dispenser body in a first phase between apre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispenser body is rotatedabout the longitudinal axis, at least in part, during the first phaseand/or the second phase for aligned orientation with at least onelocking structure during travel in the second phase.

101. A fluid dispenser comprising a barrel defining a longitudinal axisterminating at a first fluid delivery end region; a dispenser bodymovable along the barrel relative to the first fluid delivery end regionin a first phase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispenser bodyis configured to rotate about the longitudinal axis during the firstphase and/or the second phase for aligned orientation with at least onelocking structure configured to lock the dispenser body in the lockedpost-dispensing configuration during travel in the second phase.102. A fluid dispenser comprising housing means defining a longitudinalaxis terminating at a first fluid delivery end region; dispensing meansmovable along the housing means relative to the first fluid delivery endregion in a first phase between a pre-dispensing configuration and adispensed configuration, and in a second phase between the dispensedconfiguration and a locked post-dispensing configuration, wherein thedispensing means is configured to rotate about the longitudinal axisduring the first phase for aligned orientation with at least one lockingmeans during travel in the second phase.103. A fluid dispenser comprising housing means defining a longitudinalaxis terminating at a first fluid delivery end region; dispensing meansmovable along the housing means relative to the first fluid delivery endregion in a first phase between a pre-dispensing configuration and adispensed configuration, and in a second phase between the dispensedconfiguration and a locked post-dispensing configuration, wherein thedispensing means is configured to rotate about the longitudinal axisduring the first phase and/or the second phase for aligned orientationwith at least one locking means during travel in the second phase.104. A dispenser as defined in any of the preceding or followingclauses, wherein the dispensing means includes a needle support meanswith a second fluid delivery end region defined thereon.105. A dispenser as defined in any one of the preceding or followingclauses, wherein the dispensing means includes fluid capsule carriermeans movable relative to the needle support means in at least part ofthe first phase to dispense fluid from a carried capsule therein.106. A dispenser as defined in any one of the preceding or followingclauses, wherein the dispensing means includes plunger means movablerelative to the fluid capsule carrier means in at least part of thefirst phase to pressurize a carried capsule therein.107. A dispenser as defined in any of the preceding or followingclauses, wherein the needle support means is retracted to within thehousing means in the locked post-dispensing configuration.108. A dispenser as defined in any of the preceding or followingclauses, wherein the fluid capsule carrier means is configured, duringat least part of the first phase, to travel with the plunger means.109. A dispenser as defined in any of the preceding or following clauseswherein, during at least part of the first phase, the fluid capsulecarrier means is configured to rotate axially between lock-unaligned andlock-aligned angular positions.110. A dispenser as defined in any of the preceding or followingclauses, further comprising at least one rotation means provided betweenthe fluid capsule carrier means and at least one of the plunger meansand the needle support means.111. A dispenser as defined in any of the preceding or followingclauses, wherein the at least one rotation means includes a firstrotation means provided between the fluid capsule carrying means andplunger means.112. A dispenser as defined in any of the preceding or followingclauses, wherein the at least one rotation means includes a secondrotation means provided between the fluid capsule carrier means and theneedle support means.113. A dispenser as defined in any of the preceding or followingclauses, wherein the capsule carrier means is configured to receive afluid capsule to be pressurized therein by the plunger means, the fluidcapsule carrier means is configured in a first dispensing position toreceive an upstream end of a needle on the needle support means topenetrate the fluid capsule as pressurized, and the plunger means isconfigured to travel with the fluid capsule carrier means toward adispensed position to express the fluid through the needle at the firstdelivery end region.114. A dispenser as defined in any of the preceding or followingclauses, wherein the first phase includes at least in part:

a. a first rotation phase during which the fluid capsule carrier meansis rotatable relative to the needle carrier means about the longitudinalaxis, as the plunger means approaches the fluid capsule carrier means;and

b. a second dispensing phase during which the plunger means is movableaxially relative to the fluid capsule carrier means toward the dispensedposition to pressurize the capsule and dispense the fluid.

115. A dispenser as defined in any of the preceding or following claims,wherein during the second dispensing phase, at least in part, theplunger means is movable axially with the fluid capsule carrying means,toward piercing contact with a needle means on the needle carrier means,to dispense the fluid.116. A dispenser as defined in any of the preceding or followingclauses, wherein the at least one locking means is configured to fix thefluid capsule carrier means at a locking location when the fluid capsulecarrier means is in the lock-aligned angular position, the needlesupport means being biased to travel from the dispensed position towardthe locking location.117. A dispenser as defined in any of the preceding or followingclauses, wherein the at least one locking means is configured betweenthe fluid capsule carrier means and the housing means to engage when thedispensing means is in the lock-aligned angular position.118. A dispenser as defined in any of the preceding or followingclauses, wherein the bias is provided by at least one biasing meansacting between the first and second fluid delivery end regions.119. A dispenser as defined in any of the preceding or followingclauses, further comprising latch means which configured to release thedispensing means at a transition region following relative travel of thedispensing means along the longitudinal axis, toward and beyond thetransition, thereby to release the plunger means.120. A method as shown or described herein.121. A dispenser as shown or described herein.

The present disclosure describes what are considered to be practicalexemplary embodiments. It is recognized, however, that departures may bemade within the scope of the invention and that obvious modificationswill occur to a person skilled in the art. Further, the subject matterof the present disclosure supports and provides sufficient basis for anyelement, feature, structure, function, and/or step of any aspect, and/orexemplary embodiment described in the present disclosure including thefigures, clauses and/or claims herein to be combined with any other oneor more elements, features, structures, functions, and/or steps of anyaspect and/or exemplary embodiment described in the present disclosureincluding the figures, clauses and/or claims herein, as basis for anindependent or dependent claim herein. With respect to the abovedescription, it is to be realized that the dimensional relationships forthe parts of the invention, to include variations in size, materials,shape, form, function and manner of operation, assembly and use, aredeemed readily apparent and obvious to one skilled in the art, and allequivalent relationships to those illustrated in the drawings anddescribed in the specification are intended to be encompassed by thepresent invention.

Therefore, the foregoing is considered as illustrative only of theprinciples of the invention. Further, since numerous modifications andchanges may readily occur to those skilled in the art, it is not desiredto limit the invention to the exact construction and operation shown anddescribed, and accordingly, all suitable modifications and equivalentsmay be resorted to, falling within the scope of the invention.

While a device or assembly and an accompanying method have beendescribed for what are presently considered the exemplary embodiments,the invention is not so limited. To the contrary, the invention isintended to cover various modifications and equivalent arrangementsincluded within the spirit and scope of the appended claims. The scopeof the following claims is to be accorded the broadest interpretation soas to encompass all such modifications and equivalent structures andfunctions.

1. A fluid dispenser comprising a barrel defining a longitudinal axisterminating at a first fluid delivery end region; a dispenser bodymovable along the barrel relative to the first fluid delivery end regionin a first phase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispenser bodyis configured to rotate about the longitudinal axis during the firstphase for aligned orientation with at least one locking structureconfigured to lock the dispenser body in the locked post-dispensingconfiguration during travel in the second phase.
 2. A dispenser asdefined in any of the preceding or following claims, wherein thedispenser body includes a needle carrier with a second fluid deliveryend region defined thereon.
 3. A dispenser as defined in any of thepreceding or following claims, wherein the needle carrier is configuredto be in a retracted position within the barrel in the lockedpost-dispensing configuration.
 4. A dispenser as defined in any of thepreceding or following claims, wherein the dispenser body includes afluid capsule carrier moveable relative to the needle carrier in thefirst phase to dispense fluid from a carried capsule.
 5. A dispenser asdefined in any of the preceding or following claims, wherein thedispenser body includes a plunger structure movable relative to thefluid capsule carrier in at least part of the first phase to pressurizea carried capsule.
 6. A dispenser as defined in any of the preceding orfollowing claims, wherein the fluid capsule carrier is configured,during at least part of the first phase, to travel with the plungerstructure.
 7. A dispenser as defined in any of the preceding orfollowing claims wherein, during at least part of the first phase, thefluid capsule carrier is configured to rotate axially betweenlock-unaligned and lock-aligned angular positions.
 8. A dispenser asdefined in any of the preceding or following claims, further comprisingat least one rotation interface defined across a plurality ofcooperating elements respectively on the fluid capsule carrier and atleast one of the plunger structure and the needle carrier, to enableaxial rotation of the fluid capsule carrier relative to the barrel.
 9. Adispenser as defined in any of the preceding or following claims,wherein the at least one rotation interface includes a first rotationinterface provided between the fluid capsule carrier and the plungerstructure, each including one of a corresponding first set of firstcooperating elements.
 10. A dispenser as defined in any of the precedingor following claims, wherein the at least one rotation interfaceincludes a second rotation interface provided between the fluid capsulecarrier and the needle carrier, each including one of a correspondingsecond set of second cooperating elements.
 11. A dispenser as defined inany of the preceding or following claims, wherein the first and/orsecond cooperating elements include at least one guide path and at leastone follower to travel along the guide path.
 12. A dispenser as definedin any of the preceding or following claims, wherein the guide path isramped.
 13. A dispenser as defined in any of the preceding or followingclaims, wherein the fluid capsule carrier includes a capsule carrierbody comprising an open end region opposite the second fluid deliveryend region to receive the plunger structure therethrough.
 14. Adispenser as defined in any of the preceding or following claims,wherein the at least one first guide path is operatively oriented nearthe open end region to engage the first follower on the plungerstructure.
 15. A dispenser as defined in any of the preceding orfollowing claims, wherein the second guide path is operatively orientednear the second fluid delivery end region to engage the second followeron the needle carrier.
 16. A dispenser as defined in any of thepreceding or following claims, wherein the capsule carrier body iscylindrical and includes a pair of first guide paths and a pair ofsecond guide paths, each pair being symmetrically arranged relative tothe longitudinal axis.
 17. A dispenser as defined in any of thepreceding or following claims, wherein the fluid capsule carrierincludes a transverse fluid capsule receiving surface, and a needlepassage extending therethrough to receive an upstream end of a needle.18. A dispenser as defined in any of the preceding or following claims,wherein the plunger structure includes a plunger end region to travelduring at least part of the first phase toward the fluid capsulereceiving surface to pressurize the fluid capsule, thereby to expressthe fluid through the needle.
 19. A dispenser as defined in any of thepreceding or following claims, wherein the first phase includes at leastin part: a. a first rotation phase during which the fluid capsulecarrier is rotatable relative to the needle carrier about thelongitudinal axis, as the plunger end region approaches the fluidcapsule receiving surface; and b. a second dispensing phase during whichthe plunger end region is movable axially relative to the fluid capsulereceiving surface, at least in part, to pressurize the fluid capsule.20. A dispenser as defined in any of the preceding or following claims,wherein during the second dispensing phase, at least in part, theplunger end region is movable axially with the fluid capsule receivingsurface, toward piercing contact with a needle on the needle carrier, todispense the fluid.
 21. A dispenser as defined in any of the precedingor following claims, wherein the at least one locking structure includesa lock interface to fix the dispenser body at a locking location whenthe dispenser body is in the lock-aligned angular position.
 22. Adispenser as defined in any of the preceding or following claims,wherein the needle carrier is biased to travel from the second dispensedposition to the locking location.
 23. A dispenser as defined in any ofthe preceding or following claims, wherein the lock interface isconfigured between the fluid capsule carrier and the barrel to engagewhen the dispenser is in the lock-aligned angular position.
 24. Adispenser as defined in any of the preceding or following claims,further comprising at least one latch structure extending laterallyoutwardly from the fluid capsule carrier and at least one axial latchedge formation extending along an inner surface of the barrel andterminating at a transition region, wherein the latch structure isconfigured to travel along the axial latch edge formation toward andbeyond the transition, thereby to release the plunger structure.
 25. Adispenser as defined in any of the preceding or following claims,wherein the at least one locking structure and the at least one latchstructure are each defined in common by a pair of locking tabs extendingoutwardly from the fluid capsule carrier.
 26. A dispenser as defined inany of the preceding or following claims, wherein the bias is providedby at least one spring acting between the first and second fluiddelivery end regions.
 27. A dispenser as defined in any of the precedingor following claims, wherein the lock interface is configured betweenthe at least one locking structure extending laterally outwardly fromthe needle carrier and at least one transverse locking edge formationextending transversely across a surface of the barrel at the lockinglocation, wherein the locking structure is configured to travel towardand engage the transverse locking edge formation at the locking locationwhen in the lock-aligned angular position.
 28. A dispenser as defined inany of the preceding or following claims, wherein the at least onelocking structure includes at least one locking tab extending laterallyoutwardly from the fluid capsule carrier to engage a correspondinglocking edge formation on the barrel.
 29. A dispenser as defined in anyof the preceding or following claims, wherein the plunger structureincludes a plunger and a plunger support, the plunger configured toswivel through at least a predetermined range relative to the plungersupport to rotate with the fluid capsule carrier.
 30. A dispenser asdefined in any of the preceding or following claims, the fluid capsulecarrier and the plunger being configured to fix an angular position ofthe plunger relative to the fluid capsule carrier at least during thefirst phase.
 31. A dispenser as defined in any of the preceding orfollowing claims, the fluid capsule carrier and the plunger furthercomprising complementary guide formations to align the plunger with thefluid capsule carrier.
 32. A dispenser as defined in any of thepreceding or following claims, wherein the guide formations include atleast one laterally outwardly extending tab on the plunger and at leastone longitudinal groove formed in an inner surface of the fluid capsulecarrier.
 33. A dispenser as defined in any of the preceding or followingclaims, wherein the plunger support and the needle carrier areconfigured to fix an angular position of the plunger support relative tothe needle carrier.
 34. A dispenser as defined in any of the precedingor following claims, wherein the needle carrier and the plunger supportinclude complementary formations aligned with the longitudinal axis toform a plunger support travel path along the longitudinal axis.
 35. Adispenser as defined in any of the preceding or following claims,wherein the complementary formations include a pair of flanges extendingfrom one of the needle carrier and the plunger support, to be receivedin complementary groove formations on the other of the needle carrierand the plunger support.
 36. A dispenser as defined in any of thepreceding or following claims, wherein the plunger support includes acover flange laterally outwardly spaced to form an annular passage toreceive an adjacent end region on the barrel.
 37. A dispenser as definedin any of the preceding or following claims, further comprising at leastone user gripping tab extending outwardly from the needle carrier or thebarrel for a user to engage for manipulating the dispenser through atleast part of the first phase.
 38. A dispenser as defined in any of thepreceding or following claims, further comprising a signal emitter toemit a signal indicating that the plunger structure has reached adispensed position.
 39. A dispenser as defined in any of the precedingor following claims, wherein the signal emitter includes a signalemitting interface between the barrel and the dispenser body.
 40. Adispenser as defined in any of the preceding or following claims,wherein the signal emitting interface includes at least one resilienttab and at least one locking formation aligned therewith, each of whichis located on one a respective one of the barrel and the dispenser body.41. A dispenser as defined in any of the preceding or following claims,wherein the at least resilient tab extends from the plunger support andthe at least one locking formation is positioned on an inner surface ofthe barrel.
 42. A dispenser as defined in any of the preceding orfollowing claims, wherein the at least one resilient tab is locked inposition with at least one locking formation in the dispensed position.43. A dispenser as defined in any of the preceding or following claims,further comprising a lock interface to lock the dispenser body relativeto the barrel in the dispensed position.
 44. A dispenser as defined inany of the preceding or following claims, wherein the lock interfaceincludes at least one resilient tab and a boss aligned therewith, eachof which is located on one a respective one of the barrel and the body.45. A dispenser as defined in any of the preceding or following claims,wherein the resilient tab extends from the plunger support and the bossis positioned on an inner surface of the barrel.
 46. A dispenser asdefined in any of the preceding or following claims, wherein the plungersupport, the needle carrier and/or the barrel include formations to forma guide interface for inhibiting rotational movement therebetween.
 47. Adispenser as defined in any of the preceding or following claims,wherein the guide interface includes at least one support passage toreceive an extended section on the barrel.
 48. A dispenser as defined inany of the preceding or following claims, wherein the plunger supportincludes a pair of symmetrically opposed circumferentially extendedwebs, each defining an outer periphery of one of a corresponding pair ofsupport passages.
 49. A dispenser as defined in any of the preceding orfollowing claims, wherein the needle carrier includes a pair of opposedand circumferentially cross sectioned guide sections to engagecorresponding surfaces on the plunger support.
 50. A fluid dispensercomprising: a. a barrel defining a longitudinal axis terminating at afirst fluid delivery end region; b. a body movable along the barrelrelative to the first fluid dispensing end region, the body including:i. a needle carrier aligned with the longitudinal axis and terminatingat a second fluid delivery end region, at which is located a needlehaving a downstream end configured to project through the first fluiddelivery end region in a first dispensing position; ii. a plungerstructure aligned with the longitudinal axis and movable axiallyrelative to the needle carrier; and iii. a fluid capsule carrier whichis configured to receive a fluid capsule, the fluid capsule carrierbeing aligned with the longitudinal axis and movable axially relative tothe needle carrier and the plunger structure; iv. a latch interfaceoperable under the action of a compressive force between the barrel andthe body, to release the plunger structure to travel relative to theneedle carrier; and v. the fluid capsule carrier configured, in adispensing mode, to travel toward piercing contact of the needle withthe fluid capsule.
 51. A dispenser as defined in claim any of thepreceding or following claims, wherein the fluid capsule carrier isconfigured, in at least part of the dispensing mode, to travel with theplunger structure.
 52. A dispenser as defined in any of the preceding orfollowing claims, wherein, in at least part of the dispensing mode, thefluid capsule carrier is configured to rotate axially betweenlock-unaligned and lock-aligned angular positions.
 53. A dispenser asdefined in any of the preceding or following claims, further comprisingat least one rotation interface including a plurality of cooperatingelements respectively on the fluid capsule carrier and at least one ofthe plunger structure and the needle carrier.
 54. A dispenser as definedin any of the preceding or following claims, wherein the at least onerotation interface includes a first rotation interface provided betweenthe fluid capsule carrier and the plunger structure , each including oneof a corresponding first set of first cooperating elements.
 55. Adispenser as defined in any of the preceding or following claims,wherein the at least one rotation interface includes a second rotationinterface provided between the fluid capsule carrier and the needlecarrier, each including one of a corresponding second set of secondcooperating elements.
 56. A dispenser as defined any of the preceding orfollowing claims, wherein the first and/or second cooperating elementsinclude at least one guide path and at least one follower to travelalong the guide path.
 57. A dispenser as defined in any of the precedingclaims, wherein the guide path is ramped.
 58. A dispenser as defined inany of the preceding or following claims, wherein the follower in thefirst and/or second sets of cooperating elements includes a followerguide path.
 59. A dispenser as defined in any of the preceding orfollowing claims, wherein the fluid capsule carrier includes a capsulecarrier body comprising an open end region opposite the second fluiddelivery end region to receive the plunger structure therethrough,
 60. Adispenser as defined in any of the preceding or following claims,wherein at least one first guide path is operatively oriented near theopen end region to engage the first follower on the plunger structure,and at least one second guide path operatively oriented near the secondfluid delivery end region to engage the second follower on the needlecarrier.
 61. A dispenser as defined in any of the preceding or followingclaims, wherein the capsule carrier body is cylindrical and includes apair of first guide paths and a pair of second guide paths, each pairbeing symmetrically arranged relative to the longitudinal axis.
 62. Adispenser as defined in any of the preceding or following claims,wherein the fluid capsule carrier includes a fluid capsule receivingsurface, and a needle passage extending therethrough to receive theupstream end of the needle in the first dispensing position, the plungerstructure including a plunger end region to travel during the dispensingmode toward a second dispensed position adjacent the fluid capsulereceiving surface and to cooperate therewith to pressurize the fluidcapsule, thereby to express the fluid through the needle.
 63. Adispenser as defined in any of the preceding or following claims,wherein the dispensing mode includes at least in part: a. a firstrotation phase during which the fluid capsule carrier rotates relativeto the needle carrier about the longitudinal axis, while the plunger endregion approaches the fluid capsule receiving surface; and b. a seconddispensing phase during which the plunger end region is movable axiallyrelative to the fluid capsule receiving surface, at least in part, topressurize the fluid capsule and dispense the fluid.
 64. A dispenser asdefined in any of the preceding or following claims, wherein during thesecond dispensing phase, at least in part, the plunger end region ismovable axially with the fluid capsule receiving surface, towardpiercing contact with a needle on the needle carrier, to dispense thefluid.
 65. A dispenser as defined in any of the preceding or followingclaims, further comprising a lock interface to fix the body at a lockinglocation when the fluid capsule carrier is in the lock-aligned angularposition.
 66. A dispenser as defined in any of the preceding orfollowing claims, wherein the needle carrier is biased to travel fromthe second dispensed position to the locking location.
 67. A dispenseras defined in any of the preceding or following claims, wherein the biasis provided by at least one spring acting between the first and secondfluid delivery end regions.
 68. A dispenser as defined in any of thepreceding or following claims, further comprising a latch interfaceconfigured between at least one locking tab extending laterallyoutwardly from the fluid capsule carrier and at least one axial latchedge formation extending along an inner surface of the barrel andterminating at a transition region, wherein the locking tab isconfigured to travel along the axial locking edge formation under theaction of the compressive force toward and beyond the transition region,thereby to release the plunger structure for travel relative to thefluid capsule carrier.
 69. A dispenser as defined in any of thepreceding or following claims, wherein the lock interface is configuredbetween at least one locking tab extending laterally outwardly from thefluid capsule carrier and at least one transverse locking edge formationextending transversely across an inner surface of the barrel at the locklocation, wherein the locking tab is configured to travel toward andengage the transverse locking edge formation at the locking locationwhen in the lock-aligned angular position.
 70. A dispenser as defined inany of the preceding or following claims, wherein the at least onelocking tab includes a pair of locking tabs extending laterallyoutwardly from the fluid capsule carrier.
 71. A dispenser as defined inany of the preceding or following claims, wherein the plunger structureincludes a plunger and a plunger support, the plunger configured toswivel through at least a predetermined range relative to the plungersupport to rotate with the fluid capsule carrier.
 72. A dispenser asdefined in any of the preceding or following claims, the fluid capsulecarrier and the plunger being configured to fix an angular position ofthe plunger relative to the fluid capsule carrier at least during thedispensing mode.
 73. A dispenser as defined any of the preceding orfollowing claims, the fluid capsule carrier and the plunger furthercomprising complementary guide formations.
 74. A dispenser as defined inany of the preceding or following claims, wherein the guide formationsinclude at least one laterally outwardly extending tab on the plungerand at least one longitudinal groove formed in an inner surface of thefluid capsule carrier.
 75. A dispenser as defined in any of thepreceding or following claims, wherein the plunger support and theneedle carrier are configured to fix an angular position of the plungersupport relative to the needle carrier in the dispensing mode.
 76. Adispenser as defined in any of the preceding or following claims,wherein the needle carrier and the plunger support include complementaryformations aligned with the longitudinal axis to form a plunger supporttravel path along the longitudinal axis.
 77. A dispenser as defined inany of the preceding or following claims, the complementary formationsincluding a pair of flanges extending from the needle carrier toward theplunger support, to be received in complementary groove formations onthe plunger support.
 78. A dispenser as defined in any of the precedingor following claims, wherein the plunger support includes a cover flangelaterally outwardly spaced to form an annular passage to receive anadjacent end region on the barrel.
 79. A dispenser as defined in any ofthe preceding or following claims any, further comprising at least oneuser gripping tab extending outwardly from the needle carrier or thebarrel for a user to engage for manipulating the dispenser through atleast part of the dispensing mode.
 80. A dispenser as defined in any ofthe preceding or following claims, further comprising a signal emitterto emit a signal indicating that the plunger structure has reached thesecond dispensed position.
 81. A dispenser as defined in any of thepreceding or following claims, wherein the signal emitter includes asignal emitting interface between the barrel and the body.
 82. Adispenser as defined in any of the preceding or following claims,wherein the signal emitting interface includes at least one resilienttab and at least one locking formation aligned therewith, each of whichis located on one a respective one of the barrel and the body.
 83. Adispenser as defined in any of the preceding or following claims,wherein the resilient tab extends from the plunger support and at leastone locking formation is positioned on an inner surface of the barrel.84. A dispenser as defined any of the preceding or following claims,wherein the resilient tab is locked in position with the at least onelocking formation in the second dispensed position.
 85. A dispenser asdefined in any of the preceding or following claims, further comprisinga lock interface to lock the body relative to the barrel in the seconddispensed position.
 86. A dispenser as defined in any of the precedingor following claims, wherein the lock interface includes at least oneresilient tab and a boss aligned therewith, each of which is located ona respective one of the barrel and the body.
 87. A dispenser as definedin any of the preceding or following claims, wherein the resilient tabextends from the plunger support and the boss is positioned on an innersurface of the barrel.
 88. A dispenser as defined in any of thepreceding or following claims, wherein the plunger support, the needlecarrier and/or the barrel include formations to form a guide interfacefor guiding movement therebetween.
 89. A dispenser as defined in any ofthe preceding or following claims, wherein the guide interface includesat least one support passage to receive an extended section on thebarrel.
 90. A dispenser as defined in any of the preceding or followingclaims, wherein the plunger support includes a pair of symmetricallyopposed circumferentially extended webs, each defining an outerperiphery of one of a corresponding pair of support passages.
 91. Adispenser as defined in any of the preceding or following claims,wherein the needle carrier includes a pair of opposed andcircumferentially cross sectioned guide sections to engage correspondingsurfaces on the plunger support.
 92. A fluid dispenser comprising abarrel defining a longitudinal axis and terminating at a first fluiddelivery end region; a body movable along the barrel relative to thefirst fluid delivery end region, the body including a needle carrier, aplunger and a fluid capsule carrier therebetween, a latch interfacebetween the body and the barrel and responsive to a release forcetherebetween caused by compressive engagement of the barrel at a fluiddelivery site, to enable travel of the plunger and the fluid capsulecarrier toward the needle carrier, to a dispensing configuration inwhich an upstream end of a needle on the needle carrier extends into acapsule carrying region of the fluid capsule carrier and a downstreamend of the needle projects extends through the first fluid delivery endregion for delivery of a fluid thereto.
 93. A fluid dispenser comprisinga barrel defining a longitudinal axis terminating at a dispensing end; adispenser body movable along the barrel relative to the dispensing end,the dispenser body including a needle carrier, a plunger and a fluidcapsule carrier moveable relative to the needle carrier and the plunger,and a latch interface configured to release the dispenser body fortravel in the barrel in response to a release force between the barreland the dispenser body.
 94. A fluid dispenser comprising a barreldefining a longitudinal axis terminating at a dispensing end; adispenser body movable along the barrel relative to the dispensing end,the dispenser body including a needle carrier, a plunger and a fluidcapsule carrier moveable relative to the needle carrier and the plunger,and a latch interface configured to release the dispenser body fordispensing travel in the barrel in response to a compressive engagementof the dispensing end at a fluid delivery site.
 95. A fluid dispenser,comprising a fluid capsule receiver configured to form a fluid capsulepressuring zone in a first capsule pressurizing mode, a needle carriersupporting a fluid delivery needle, the needle carrier and the fluidcapsule receiver configured to cause the needle to extend into the fluidcapsule pressurizing zone to pierce the pressurized fluid capsule in asecond fluid capsule piercing mode; and a body containing the fluidcapsule receiver and the needle carrier, the fluid capsule receiver andthe needle carrier configured to move along the body to expose a fluiddelivery end of the needle in a third fluid delivery mode.
 96. Adispenser as defined in any of the preceding or following claims,wherein the fluid capsule receiver includes a plunger and a fluidcapsule carrier, the plunger and fluid capsule carrier havingcomplementary surfaces to locate the fluid capsule therebetween.
 97. Adispenser as defined in any of the preceding or following claims,further comprising a plunger support to support the plunger, at leastone interface operable between the plunger support, the fluid capsulecarrier, the needle carrier and/or the body to enable displacement ofthe plunger relative to the fluid capsule carrier in the first, secondand/or third modes while exerting a compressive force at substantiallyconsistent magnitude between the plunger support and the body.
 98. Amethod of dispensing a fluid from a fluid capsule, comprising: a.locating a fluid capsule on a fluid capsule support surface; b.displacing a plunger along an axis to toward engagement with the fluidcapsule; c. pressurizing the fluid capsule between the plunger and thefluid capsule support surface, so that a membrane of the fluid capsuleagainst the fluid capsule support surface is in a tensioned needlereceiving configuration; d. displacing the plunger and the fluid capsulesupport, with the fluid capsule in the needle receiving configurationtoward a needle support to cause a capsule-piercing end of a fluiddelivery needle thereon, to extend through the fluid capsule supportsurface to penetrate the membrane to initiate onset of dispensing offluid through the needle; and e. advancing the plunger, the fluidcapsule support and the needle support toward a fluid deliveryconfiguration with an opposite fluid delivery end of the needle exposedto penetrate a delivery location.
 99. A method of securing a dispensingdevice following delivery of a fluid therefrom, comprising providing abarrel defining a longitudinal axis terminating at a first fluiddelivery end region and a dispenser body movable along the barrelrelative to the first fluid delivery end region, the dispenser bodymovable in a first phase between a pre-dispensing configuration and adispensed configuration, and in a second phase between the dispensedconfiguration and a locked post-dispensing configuration, wherein thedispenser body is configured to rotate about the longitudinal axis, atleast in part, during the first phase for aligned orientation with atleast one locking structure during travel in the second phase.
 100. Amethod of securing a dispensing device following delivery of a fluidtherefrom, comprising: a. providing a barrel defining a longitudinalaxis terminating at a first fluid delivery end region and a dispenserbody movable along the barrel relative to the first fluid delivery endregion; b. displacing the dispenser body in a first phase between apre-dispensing configuration and a dispensed configuration, and in asecond phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispenser body is rotatedabout the longitudinal axis, at least in part, during the first phaseand/or the second phase for aligned orientation with at least onelocking structure during travel in the second phase.
 101. A fluiddispenser comprising a barrel defining a longitudinal axis terminatingat a first fluid delivery end region; a dispenser body movable along thebarrel relative to the first fluid delivery end region in a first phasebetween a pre-dispensing configuration and a dispensed configuration,and in a second phase between the dispensed configuration and a lockedpost-dispensing configuration, wherein the dispenser body is configuredto rotate about the longitudinal axis during the first phase and/or thesecond phase for aligned orientation with at least one locking structureconfigured to lock the dispenser body in the locked post-dispensingconfiguration during travel in the second phase.
 102. A fluid dispensercomprising housing means defining a longitudinal axis terminating at afirst fluid delivery end region; dispensing means movable along thehousing means relative to the first fluid delivery end region in a firstphase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispensing meansis configured to rotate about the longitudinal axis during the firstphase and/or the second phase for aligned orientation with at least onelocking means during travel in the second phase.
 103. A fluid dispensercomprising housing means defining a longitudinal axis terminating at afirst fluid delivery end region; dispensing means movable along thehousing means relative to the first fluid delivery end region in a firstphase between a pre-dispensing configuration and a dispensedconfiguration, and in a second phase between the dispensed configurationand a locked post-dispensing configuration, wherein the dispensing meansis configured to rotate about the longitudinal axis during the firstphase for aligned orientation with at least one locking means duringtravel in the second phase.
 104. A dispenser as defined in any of thepreceding or following claims, wherein the dispensing means includes aneedle support means with a second fluid delivery end region definedthereon.
 105. A dispenser as defined in any one of the preceding orfollowing claims, wherein the dispensing means includes fluid capsulecarrier means movable relative to the needle support means in at leastpart of the first phase to dispense fluid from a carried capsuletherein.
 106. A dispenser as defined in any one of the preceding orfollowing claims, wherein the dispensing means includes plunger meansmovable relative to the fluid capsule carrier means in at least part ofthe first phase to pressurize a carried capsule therein.
 107. Adispenser as defined in any of the preceding or following claims,wherein the needle support means is retracted to within the housingmeans in the locked post-dispensing configuration.
 108. A dispenser asdefined in any of the preceding or following claims, wherein the fluidcapsule carrier means is configured, during at least part of the firstphase, to travel with the plunger means.
 109. A dispenser as defined inany of the preceding or following claims wherein, during at least partof the first phase, the fluid capsule carrier means is configured torotate axially between lock-unaligned and lock-aligned angularpositions.
 110. A dispenser as defined in any of the preceding orfollowing claims, further comprising at least one rotation meansprovided between the fluid capsule carrier means and at least one of theplunger means and the needle support means.
 111. A dispenser as definedin any of the preceding or following claims, wherein the at least onerotation means includes a first rotation means provided between thefluid capsule carrying means and plunger means.
 112. A dispenser asdefined in any of the preceding or following claims, wherein the atleast one rotation means includes a second rotation means providedbetween the fluid capsule carrier means and the needle support means.113. A dispenser as defined in any of the preceding or following claims,wherein the capsule carrier means is configured to receive a fluidcapsule to be pressurized therein by the plunger means, the fluidcapsule carrier means is configured in a first dispensing position toreceive an upstream end of a needle on the needle support means topenetrate the fluid capsule as pressurized, and the plunger means isconfigured to travel with the fluid capsule carrier means toward adispensed position to express the fluid through the needle at the firstdelivery end region.
 114. A dispenser as defined in any of the precedingor following claims, wherein the first phase includes at least in part:a. a first rotation phase during which the fluid capsule carrier meansis rotatable relative to the needle carrier means about the longitudinalaxis, as the plunger means approaches the fluid capsule carrier means;and b. a second dispensing phase during which the plunger means ismovable axially relative to the fluid capsule carrier means toward thedispensed position to pressurize the capsule and dispense the fluid.115. A dispenser as defined in any of the preceding or following claims,wherein during the second dispensing phase, at least in part, theplunger means is movable axially with the fluid capsule carrying means,toward piercing contact with a needle means on the needle carrier means,to dispense the fluid.
 116. A dispenser as defined in any of thepreceding or following claims, wherein the at least one locking means isconfigured to fix the fluid capsule carrier means at a locking locationwhen the fluid capsule carrier means is in the lock-aligned angularposition, the needle support means being biased to travel from thedispensed position toward the locking location.
 117. A dispenser asdefined in any of the preceding or following claims, wherein the atleast one locking means is configured between the fluid capsule carriermeans and the housing means to engage when the dispensing means is inthe lock-aligned angular position.
 118. A dispenser as defined in any ofthe preceding or following claims, wherein the bias is provided by atleast one biasing means acting between the first and second fluiddelivery end regions.
 119. A dispenser as defined in any of thepreceding or following claims, further comprising latch means whichconfigured to release the dispensing means at a transition regionfollowing relative travel of the dispensing means along the longitudinalaxis, toward and beyond the transition, thereby to release the plungermeans.
 120. A method as shown or described herein.
 121. A dispenser asshown or described herein.